BECN1 and ischemic stroke: The results indicated that the levels of LC3 II/I ratio and Beclin-1 increased with time, whereas those of P62, p-mTOR/mTOR, and p-P70S6K/P70S6K were reduced in mouse brain after I/R (Figure 2F and 2G) and N2a cells after OGD/R (Figure 2J and 2K), confirming the existence of autophagy in ischemic stroke.