Furthermore, in pancreatic cancer, COX-2 can promote angiogenesis in the EGFR/p38-dependent manner [48], while in chronic obstructive pulmonary disease, MSC-induced airway inflammation and emphysema are partially mediated by silencing COX-2 via the p38 and ERK pathways [49]. The gene discussed is EGFR; the disease is chronic obstructive pulmonary disease.