ZBTB20 and Alzheimer disease: Because we cannot exclude the possibility that even modest degrees of Zbtb20 deficiency in some cell types sensitize mice to alterations caused by FAD-mutant hAPP or Aβ, it is advisable to validate discoveries made in the hAPP-J20 line in independent experimental models, human AD or both, as done in several previous studies (Mucke et al., 2000; Palop et al., 2003; Chin et al., 2005; Cheng et al., 2007; Roberson et al., 2011; Verret et al., 2012; Orr et al., 2015, 2018; Vossel et al., 2016; Merlini et al., 2019; Johnson et al., 2020).