ZBTB20 and Alzheimer disease: We rigorously tested and refuted two main hypotheses: (1) the insertional mutation of hAPP-J20 mice knocks out the affected Zbtb20 allele and lowers Zbtb20 levels in AD-relevant brain regions to those found in Zbtb20+/– mice, and (2) Zbtb20+/– mice develop prominent neural network and behavioral abnormalities similar to those observed in hAPP-J20 mice.