MAPT and neurodegenerative disease: As our group previously described the presence of pancreatic α-synuclein deposits in subjects with synucleinopathies, as well as deposits of tau and Aβ in subjects with AD [39, 40], we also conducted a examination to evaluate whether in addition to an increase in total protein immunoreactivity, we also found mixed pathologies in the pancreatic β-cells of subjects with neurodegenerative diseases.