Conversely, the MC1 antibody detects advanced conformational changes in tau prior to tau aggregates becoming argyrophilic [30], and while MC1 immunoreactivity was found in 42% of subjects with DLB, such isoforms were detected in more than 85% of subjects with AD with high neuropathologic changes, suggesting that although subjects with synucleinopathies have hyperphosphorylated tau deposits, as happens in the brain, some conformational changes seem to be specific to AD subjects, even in pancreatic β-cells. Here, ATP7A is linked to Alzheimer disease.