In turn, the expression of tau phosphorylated at Ser202-Thr205, Thr212-Ser214, Thr231 and Ser422 (Fig. 1a, d–f) was more enhanced in subjects with synucleinopathies than in controls (p = 0.003 for Ser202-Thr205, p = 0.0025 for Thr212-Ser214, p = 0.0424 for Thr231 and p = 0.0316 for Ser422) and in subjects with a normal neuropathological examination and a history of T2DM (p = 0.0101 for Ser202-Thr205, p = 0.0055 for Thr212-Ser214, p = 0.0456 for Thr231 and p = 0.0316 for Ser422). Here, MAPT is linked to type 2 diabetes mellitus.