P2RY12 and early-onset autosomal dominant Alzheimer disease: In the APP/PS1 mouse model of Alzheimer’s disease, we have observed that SCF + G-CSF treatment also increases the process complexity of microglia and enhances the expression of P2RY12 and TMEM119 positive homeostatic microglia in the brain [80], suggesting that SCF + G-CSF improves the homeostasis of the neuronal microenvironment.