All in all, we found circ-MBOAT2 silencing repressed pancreatic cancer progression via regulating cell proliferation, apoptosis, migration, invasion through repressing glutamine catabolism, and the underlying mechanism was that circ-MBOAT2 induced GOT1 expression via absorbing miR-433-3p (Figure S6). The gene discussed is GOT1; the disease is pancreatic neoplasm.