The aim of this study was to examine whether rotating between two drugs with a different (yet partially overlapping) mutational profile could postpone the emergence of resistance in FLT3\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$^+$$\end{document}+-AML. Here, FLT3 is linked to acute myeloid leukemia.