As previously reported, FZD2 is dysregulated in various cancer types, such as oral squamous cell carcinoma (OSCC) [4], gastric cancer (GC) [5], endometrial cancer (EC) [6], hepatocellular carcinoma (HCC) [7] and tongue squamous cell carcinoma (TSCC) [8]. Here, FZD2 is linked to hepatocellular carcinoma.