For example, “cGMP − PKG signaling pathway,” “Cardiac muscle contraction,” “Calcium signaling pathway,” and “Adrenergic signaling in cardiomyocytes” were downregulated, which was consistent with the pathophysiological changes of sepsis-induced myocardial depression and also similar to the GO enrichment results, indicating the critical role of TUCPs in regulating heart contraction. The gene discussed is PRKG1; the disease is Sepsis.