Regarding ANKDD1A, previous reports have suggested that it is a functional tumor suppressor gene, especially in the hypoxic microenvironment, that can inhibit the growth of glioblastoma multiforme (GBM) by inhibiting the transcriptional activity of hypoxia-inducible factor 1α (HIF1α), reducing the half-life of HIF1α, reducing glucose secretion, and inhibiting the production of lactic acid (Feng et al. 2018). This evidence concerns the gene HIF1A and glioblastoma.