MAPK3 and cancer: Circ-BANP functions as a miR-503 sponge, and miR-503 targets 3′-untranslated region (UTR) of La-related protein 1 mRNA.[39] La-related protein 1has been validated as an oncogene in NSCLC, and it stabilizes mammalian target of rapamycin (mTOR), sustaining mTOR signaling and promoting cancer cell growth.[40,41] CircFGFR3 acts as a miR-22-3p sponge, and miR-22-3p targets galectin-1 mRNA.[42] galectin-1mediates phosphorylation of protein kinase B (AKT) and extracellular signal-regulated kinase 1/2 by circFGFR3, which is required for tumor-promoting effects in NSCLC cell models 95D and A549.