TMEM14A is desregulated in multiple cancers.[70] Knockdown of TMEM14A in ovarian cancer A2780 and HO-8910 cells downregulates TGF-β/Smad signaling, arrests cell cycle and suppresses cell proliferation, migration and invasion, suggesting the oncogenic role of TMEM14A.[71] Hsa_circ_0003998 is a competing endogenous RNA for miRNA-326.[72] Its increase leads to blocking of the inhibitory effect of miRNA-326 on Notch1. The gene discussed is NOTCH1; the disease is ovarian carcinoma.