EZH2 and neoplasm: GAGE has also been shown to express in NSCLC tissues, and higher level indicates advanced clinical stages.[89] Hsa_circ_0020123 inhibits miR-144.[90] Inhibition of miR-144 promotes expression of zinc finger E-box-binding homeobox 1 (ZEB1), and ZEB1 promotes tumor invasion and migration by inducing epithelial mesenchymal transition.[91] Another miR-144 target EZH2 is a histone methyltransferase.