LIFR inhibits tumor metastasis via the Hippo-YAP pathway, and this tumor suppressive role of LIFR has been observed in multiple cancer, including lung cancer.[123,124] Hsa_circ_0006427 serves as a miR-6783-3p sponge.[125] MiR-6783-3p targets a Wnt/β-catenin pathway inhibitor DKK1. This evidence concerns the gene LIFR and lung cancer.