Because Wnt signaling pathway impacts NSCLC tumorigenesis, prognosis and therapy resistance, inactivation of Wnt/β-catenin signaling by miR-6783-3p inhibition results in tumor suppression.[126] Hsa_circ_0007874 functions as a miR-17 sponge.[127] Inhibition of miR-17 results in upregulation of QKI-5, further resulting in downregulation of Notch intracellular domain and 2 downstream genes of Notch pathway, HES1 and Hey2.[127] Notch signaling plays multiple roles in lung cancer tumorigenesis and is associated with survival.[128] Thus, inhibition of Notch signaling might suppress lung cancer. The gene discussed is HES1; the disease is lung cancer.