Cui et al find that UCA1 promotes colon cancer progression by binding to miR-28-5p and regulates HOXB3 expression.[26] Cao et al find that UCA1 inhibits the carcinogenesis and metastasis of colon cancer by regulating the miR-185-5p/MAPK14/MAPKAPK2/HSP27 axis.[27] In our study, we find that UCA1 expression is upregulated in colon cancer and is associated with early tumor stage. This evidence concerns the gene HOXB3 and malignant colon neoplasm.