SHMT2 and malignant colon neoplasm: CeRNA plays an important role in the occurrence and development of cancer.[12] Qiong Wu et al found that lncRNA MALAT1 regulated HMGB1 expression by sponging miR-129-5p to induce colon cancer development.[13] Changwei Lin et al found that LINC01234 upregulated SHMT2 expression by competitively binding to miR-642a-5p to promote colon cancer proliferation.[14]