However, it has been also reported that API2-MALT1 positive gastric MALT lymphomas showed rather favorable prognosis such as no progression of clinical stage, high-grade transformation, or chromosomal aberrations.[7,8] Here, we show a case of H. pylori negative gastric MALT lymphoma with API2-MALT1 translocation successfully treated by endoscopic submucosal dissection (ESD). Here, BIRC3 is linked to MALT lymphoma.