The API2-MALT1 positive gastric MALT lymphomas show no progression of clinical stage, high-grade transformation, or chromosomal aberrations.[7,8] A “watch and wait” strategy is sometimes considered for the cases with persistent histological lymphoma without progression.[9] On the other hand, radiotherapy is also effective for localized cases,[3,6] which can be considered for cases resistant to H. pylori eradication. This evidence concerns the gene BIRC3 and MALT lymphoma.