The PLN p.Arg14del variant (NM_002667.5(PLN):c.37_39AGA[1]) was first identified in ARVC in a cohort of 12/97 patients fulfilling TFC.27 Histology showed the typical fibro-fatty replacement and interstitial fibrosis yet compared with desmosomal gene-positive patients, PLN p.Arg14del showed significantly more severe fibrotic changes in the left ventricle, underscoring its biventricular character.28 This evidence concerns the gene PLN and Arrhythmogenic right ventricular dysplasia.