As shown in Figure 2, based on initial scoring, 6 genes (PKP2, DSP, DSC2, DSG2, JUP, and TMEM43) had strong evidence (12–18 points) and were judged to be definitive for ARVC causation as each had replication across ARVC cohorts. Here, TMEM43 is linked to arrhythmogenic right ventricular cardiomyopathy.