Ten genes had limited evidence for ARVC causality (1–6 points): SCN5A, LMNA, CDH2, CTNNA3, TGFB3, TTN, TJP1, MYH7, MYBPC3, and MYL3. In comparison to the wealth of literature linking desmosomal genes with ARVC, evidence for these gene:disease relationships had been generated by relatively few research groups. The gene discussed is TJP1; the disease is arrhythmogenic right ventricular cardiomyopathy.