PubMed/OMIM searches resulted in 26 genes reported to cause human ARVC: ACTC1, CDH2, CTNNA3, LDB3, DES, DSC2, DSG2, DSP, JUP, LMNA, MYBPC3, MYH7, MYL2, MYL3, PKP2, PLN, RYR2, SCN5A, TGFB3, TJP1, TMEM43, TNNI3, TNNC1, TNNT2, TPM1, and TTN (Table 1). The gene discussed is SCN5A; the disease is arrhythmogenic right ventricular cardiomyopathy.