The HOME trial (Hyperinsulinaemia: the Outcomes of its Metabolic Effects), a 4.3 year placebo-controlled randomized trial in patients with advanced T2D, defined as failure of maximal oral antidiabetic treatment (HbA1c > 7.5%) and need for exogenous insulin, showed that metformin added to insulin prevented weight gain, improved glycemic control and reduced insulin requirements [2]. Here, INS is linked to type 2 diabetes mellitus.