With the present study focused on CNS residential cells, it will be interesting to examine the time course of Treg infiltration, which starts at 5 days after stroke and escalates until at least 2 months after stroke (Ito et al., 2019). The eventual translation of the present in vitro study into an in vivo stroke model will further reveal the potentiation effects of IL-2 on Tregs neurovascular protection. Here, IL2 is linked to Stroke.