While AD is considered a separate entity, PSP, CBD, AGD, PiD and CTE fall into the category of FTLD pathologies related to tau (FTLD-tau) which distinguishes them from FTLDs associated with TAR DNA-binding protein (TDP-43), fused in sarcoma (FUS) or charged multivesicular body protein 2B (CHMP2B). This evidence concerns the gene CHMP2B and Alzheimer disease.