Finally, a region on chromosome 1p31.3, near PGM1, co-localised (H4PP=0.91, ESM Fig. 3), with the minor T allele at the type 2 diabetes index variant rs2269247 (C>T) decreasing risk of type 2 diabetes (OR 0.96, p=4.6×10-7) and increasing risk of type 1 diabetes (OR 1.15, p=1.9×10-6) (Table 1). This evidence concerns the gene PGM1 and type 1 diabetes mellitus.