Third, a region on chromosome 4p16.3 co-localised (H4PP=0.97) (Fig. 1), near TMEM129. The minor T allele at the type 2 diabetes index variant, rs56337234 (C>T), was associated with decreased risk of type 2 diabetes (OR 0.94, p=1.4×10-17) and increased risk of type 1 diabetes (OR 1.12, p=4.07×10-6). Here, TMEM129 is linked to type 1 diabetes mellitus.