CRTC1 (also known as MECT1, TORC1, WAMPT1) belongs to the CREB-regulated transcription coactivator (CRTC) family with 3 members (CRTC1–3) that play critical roles in metabolism, aging, memory, and cancer (21), while MAML2 is a member of the mastermind-like coactivator family that is integral for Notch receptor–mediated transcriptional activation and important in development and disease, including cancer (25). Here, CALR is linked to cancer.