The t(11;19) translocation is occasionally the sole cytogenetic alteration in MEC salivary gland tumors (23) and is also detected in nonsalivary gland MEC–like tumors throughout the body (8, 10), suggesting that the acquired CRTC1-MAML2 fusion is an early core event in MEC pathogenesis. Here, MAML2 is linked to mucoepidermoid carcinoma.