The p16-positive cells were detected in both mouse MEC tumors and normal salivary glands, with an increased number of p16-positive cells in the tumors (Supplemental Figure 11B), while the CDK4-positive cells were only detected in mouse MEC tumors and not in normal salivary glands (Supplemental Figure 11C). This evidence concerns the gene CDKN2A and mucoepidermoid carcinoma.