Additionally, KDM5B has been found to bind directly to the miR‐448 promoter region and thus suppress its expression in papillary thyroid cancer cells; KDM5B knockdown induced up‐regulation of miR‐448, which abolished the promoting effect of KDM5B on the malignant characteristics of cancer cells.13 Here, KDM5B is linked to thyroid gland papillary carcinoma.