Besides, the expression of KDM5B, miR‐448, YTHDF3 and ITGA6 in mouse tumour tissues was measured by RT‐qPCR; the results revealed that up‐regulation of KDM5B reduced miR‐448 expression, while up‐regulating KDM5B, YTHDF3 and ITGA6 expression. The gene discussed is KDM5B; the disease is neoplasm.