Also, Alashi et al. found that the combination of LV GLS and brain natriuretic peptide (BNP) was associated with persistent postoperative LV dysfunction and increased mortality, independent of other clinical or echocardiographic parameters in asymptomatic patients with significant primary mitral regurgitation and preserved systolic function undergoing mitral valve surgery [28]. The gene discussed is NPPB; the disease is mitral valve insufficiency.