Interestingly, expression of TNF and CXCL1 was higher in monocytes from male individuals than in those from females; this applied to both Ly6Chi monocytes in the murine model of amebiasis and CXCL1 in LPS-stimulated CD14++CD16- monocytes from healthy human subjects [48]. This evidence concerns the gene CXCL1 and amebiasis.