CXCR5 and Familial prostate cancer: CXCR5, also known as Burkitt's lymphoma receptor 1, is abnormally increased in a variety of tumors such as gastric cancer [38], breast cancer [39, 40], intestinal cancer [41], prostate cancer [42], malignant neuroblastoma [43], and lung cancer [44], and it is significantly associated with poor prognosis.