SKP2 and cancer: In cancer, the 14-3-3ζ is substantially upregulated in various carcinomas, where it has been proposed to enhance cancer cell survival through binding of the p85 subunit of the PI3K resulting in activation of AKTs and/or by impairing tumor cell senescence in a STAT3/SKP2/p27-dependent manner (Neal et al., 2012; Lee et al., 2014).