Despite the conserved regulation of cancer cell properties like proliferation, migration, invasion and metastasis, conserved effector pathways and target RNAs of IGF2BP1 in cancer remain largely elusive (Stöhr et al., 2012; Hamilton et al., 2013; Gutschner et al., 2014; Busch et al., 2016; Müller et al., 2019; Rosenfeld et al., 2019; Müller et al., 2020). The gene discussed is IGF2BP1; the disease is cancer.