In addition, 14-3-3ζ was proposed to promote cytoplasmic accumulation of FOXO3a, modulates Wnt5A/ROR1 signaling and contributes to the switch from tumor suppressor activity of TGFβ to a pro-metastatic and pro-proliferative activity reviewed in Fan et al. (2019). The gene discussed is ROR1; the disease is neoplasm.