SCN5A and catecholaminergic polymorphic ventricular tachycardia: SCN5A genetic alterations are present in 30% of all Brugada syndrome cases while the RYR2 genetic alterations are reported because of catecholaminergic polymorphic ventricular tachycardia, atrial fibrillation, and arrhythmogenic right ventricular cardiomyopathy.