SCN5A genetic alterations are present in 30% of all Brugada syndrome cases while the RYR2 genetic alterations are reported because of catecholaminergic polymorphic ventricular tachycardia, atrial fibrillation, and arrhythmogenic right ventricular cardiomyopathy. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.