DNASE1L3 and systemic lupus erythematosus: New findings on DNase activity in patients with lupus nephritis also support the idea that NETs accumulate in the serum for a defective removal; an ancillary result is that, in SLE patients, the serum levels of DNaseI and DNaseIL3 are normal, suggesting that DNase inhibition is a potential mechanism for the DNase functional defect.