Over the past decades, there are many studies that explore the alterations of Grb2, especially in renal cell cancer, podocyte fibrosis, cardiac hypertrophy, and myocardial remodeling (Mohanty and Bhatnagar, 2018; Chang et al., 2019; Sun et al., 2019) as we have introduced earlier. This evidence concerns the gene GRB2 and cardiac hypertrophy.