GRB2 and TCF12-related craniosynostosis: Taken together, our study is aimed to investigate: (1) whether Grb2 is affected by AKI and consequently triggers cardiac dysfunction in CRS-3, (2) what the upstream molecular mechanism underlying Grb2-triggered cardiomyocyte damage is, and (3) what the intracellular events in response to Grb2 upregulation during AKI are.