STING1 and infection: Moreover, c-di-AMP from bacteria activates the cytosolic surveillance pathway leading to the induction of type I interferons (IFNs) during infection (Woodward et al., 2010; Yang et al., 2014; Dey et al., 2015), which is mediated by the stimulator of interferon genes (STING) (Burdette et al., 2011).