Six types of immune infiltrates were identified in human tumors, which corresponded from tumor promoting to tumor suppressing respectively (17), namely C1 (wound healing), C2 (INF-γ dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet) and C6 (TGF-β dominant) [29]. This evidence concerns the gene TGFB1 and neoplasm.