found that exosomes secreted by M2-type neutrophils regulate the invasion and migration behavior of colorectal cancer cells, which are rich in overexpressed miR-21-5p and miR-155-5p that bind to the coding sequence of BRG1 and lead to a decrease in BRG1 expression, thus playing an important role in the development of colorectal cancer (47).Tumor cell-derived exosomes containing CEMIP proteins promote cancer cell colonization in brain metastases. The gene discussed is CEMIP; the disease is neoplasm.