By upregulating the pro-inflammatory cytokines encoded by Tnf, Ptgs2 and Ccl/Cxcl, the uptake of CEMIP-positive exosomes by brain endothelial cells and microglia can induce differentiation and inflammation of perivascular endothelial cells, thereby promoting vascular remodeling and tumor metastasis. Here, CEMIP is linked to neoplasm.