PTEN and Familial prostate cancer: For example, Chen et al. showed that BLM protein could promote cell proliferation and inhibit apoptosis via activating AKT signaling and downregulating the PTEN expression in prostate cancer cells (61); Arora et al. via analyzing molecular profiling in a large cohort of 1,980 breast cancer samples, found that BLM mRNA overexpression was linked to a poor breast cancer-specific survival and that high cytoplasmic BLM indicated aggressive phenotypes (62).