All of these CpG probes flank the CLDN1 promoter CpG island in the 5’ shore (cg03623835), 3’ shore (cg25330387, cg00804587) and 3’ shelf (cg03601836) suggesting that the surrounding regions of the promoter CpG island are potential “hotspots” for tumor control of transcription via altering epigenetic regulation. Here, CLDN1 is linked to neoplasm.