IDH1 and central nervous system cancer: Patients with isocitrate dehydrogenase 1 (IDH1) mutated gliomas have been found more likely to develop pre-operative seizures than wild-type IDH1 (18, 19); this could be due to the excitatory effect of the d-2-hydroxyglutarate product of mutant IDH1 on NMDA receptors (20).