Older age (> 75)ObesityProlonged immobility, leg paresisPrior thromboembolic eventsMultiple medical comorbiditiesA and AB blood typeGrading (HGG > LGG)Intraluminal thrombosis (surgical specimens)Subtotal tumor resectionRecurrent diseaseTumor size (> 5 cm)IDH1 wild-type statusPost-operative periodChemotherapyAnti-VEGF treatment (bevacizumab). The gene discussed is VEGFA; the disease is neoplasm.