KEGG pathway analysis also indicates that these two modules were mainly involved in the cancer pathways, such as MAPK signaling pathway, insulin signaling pathway, p53 signaling pathway, TGF-beta signaling pathway, mTOR signaling pathway, VEGF signaling pathway, and other different pathways that are closely connected with the pathogenesis of AML [51, 52]. This evidence concerns the gene TP53 and acute myeloid leukemia.