Auger-Messier et al. (2013) suggested that the disruption of DUSP1 promoted p38 MAPK activity, which could reduce cardiac contractility and calcium handling; thus, DUSP1 could be a target gene for prevention of HF. In addition, LHFPL2 and SNX24 are associated with coronary artery disease (Lin et al., 2013; Shendre et al., 2017). HIST1H4B is associated with the immune process (Zhang et al., 2019). OXER1 is involved in the inflammatory response of the disease (Dattilo et al., 2015). This evidence concerns the gene LHFPL2 and coronary artery disorder.