LHFPL2 and hydrops fetalis: Auger-Messier et al. (2013) suggested that the disruption of DUSP1 promoted p38 MAPK activity, which could reduce cardiac contractility and calcium handling; thus, DUSP1 could be a target gene for prevention of HF. In addition, LHFPL2 and SNX24 are associated with coronary artery disease (Lin et al., 2013; Shendre et al., 2017). HIST1H4B is associated with the immune process (Zhang et al., 2019). OXER1 is involved in the inflammatory response of the disease (Dattilo et al., 2015).