C4B and cyclic hematopoiesis: Of these 10 studies, seven used trios and patterns of Mendelian inheritance to infer CH variants (Valentine et al., 2014; Spinella et al., 2015; Diets et al., 2018; Diness et al., 2018; Zhang et al., 2018; Maciaszek et al., 2019; Schieffer et al., 2019), two used computational phasing without the use of trio data (Gröbner et al., 2018; Waszak et al., 2018), and one used patient RNA-seq data to confirm the presence of a single CH variant (Zhang et al., 2015).