ACE2 and systemic lupus erythematosus: Recently, epigenetic dysregulation via hypomethylation of ACE2 coupled with demethylation of interferon and cytokine-regulated genes, and enhanced NF-kB (nuclear factor kappa light chain enhancer of activated B cells) have been shown to contribute to disease severity in SARS-CoV-2-infected patients with lupus (Sawalha et al., 2020).