Because both age and gender correlate with hypomethylation of the ACE2 gene in the lung tissue, it may have the potential to provide a possible explanation for age-and gender-related mortality seen with SARS-CoV-2 infection during COVID-19 pandemic, especially in elderly men and smokers characterized by hypomethylation of ACE2-and-interferon genes (Pinto et al., 2020). The gene discussed is ACE2; the disease is COVID-19.