We then quantify BCMA in samples collected from subjects participating in Dukoral® and clinical trials of an oral enterotoxigenic Escherichia coli (ETEC) vaccine (15–18) and demonstrate that BCMA levels in ALS specimens reflect antigen-specific ALS IgA responses to cholera and ETEC vaccines. The gene discussed is CD79A; the disease is amyotrophic lateral sclerosis.