IL10 and Sepsis: Interferon gamma (IFN-γ) has been trialed in sepsis patients and its use was associated with restoration of immune functions with increased HLA-DR expression in monocytes, increased production of cytokines such as tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and decreased production of interleukin-6 (IL-6) and interleukin-10 (IL-10) (18, 19).