In conclusion, we found that the inactivation of pVHL in pheochromocytoma led to the up-regulation of the seven novel genes, such as CTGF, SDCBP, CYR61, COL3A1, COL1A1, COL5A2, and SERPINE1. Here, COL5A2 is linked to hereditary pheochromocytoma-paraganglioma.