FOXO1 and myocardial infarction: In the case of myocardial infarction, total cardiac FOXO1 expression is downregulated at first and partly recovers after 7 days, which is accompanied by fundamental PTMs in FOXO1, particularly acetylation, suggesting that FOXO1 acetylation contributes to cardiac remodeling in post-ischemic heart failure (Kappel et al., 2016).