Researchers have found that autophagy induced by cytosolic FOXO1 is capable of suppressing tumor (Zhao et al., 2010) and that, in pancreatic cancer, miR-138-5p inhibits autophagy by blocking the SIRT1/FoxO1/Rab7 axis (Tian et al., 2017). This evidence concerns the gene FOXO1 and familial pancreatic carcinoma.