ADORA2A and Cognitive impairment: Several literature data report the use of pharmacological and genetic approaches to demonstrate that A2A adenosine receptors block prevents synaptic damage and cognitive impairments in animal models following Aβ exposure, suggesting that A2A receptor antagonists might reduce synaptotoxicity (Dall'Igna et al., 2007; Canas et al., 2009; Orr et al., 2018).