Specifically, it plays an essential role in activated microglia, located near amyloid plaques typical of AD (Franco et al., 2020), where its upregulation is responsible for a raise of M1 microglial markers (IL-1β, IL-6, TNF-α) and its antagonism prevents hippocampal LTP impairments, as well as IL-1β production, paventing a regulatory function for it in reducing memory dysfunction (Colella et al., 2018; Franco et al., 2019). The gene discussed is TNF; the disease is Alzheimer disease.