It is known that Th2-type cytokines (IL-4, IL-5, and IL-13) and epithelial-derived innate type-2 cytokines (TSLP) increased in skin lesions of acute stage of AD (DeVore et al., 2020; Edslev et al., 2020; Langan et al., 2020). This evidence concerns the gene IL13 and Alzheimer disease.