Since neurodegeneration involves the death of neurons leading to irreversible brain injury and, considering that amyloid aggregation is one of the first events of the deleterious cascade that takes place in tauopathies, it is plausible to think that drugs such as doxycycline that inhibit tau aggregation would be more suitable candidates for preventive rather than for palliative therapy. Here, MAPT is linked to tauopathy.