For assessment of clinical depression state in the independent test cohort, DOCK10, decreased in expression in low mood, had an AUC of 73% (p = 1.17E−03) across all subjects, and 75% (p = 1.05E−03) in males, surviving Bonferroni correction for all 26 biomarkers tested. The gene discussed is DOCK10; the disease is major depressive disorder.