Through the KEGG enrichment analysis of methylated differentially expressed genes, the results showed that differentially methylated genes at CCGG sites were significantly enriched in the pentose phosphate pathway, cell cycle, and disease; differentially methylated genes at CCWGG sites were significantly enriched in virus infection and glycerophosphate metabolism, and the PI3K Akt signaling pathway was the most abundant pathway. The gene discussed is AKT1; the disease is viral infectious disease.