CASP8 mRNA expression levels were found to be consistently elevated across datasets in primary prostate cancer when compared to non-cancerous prostate tissues while S100A4 mRNA was differentially expressed between primary cancer and non-cancerous prostate tissues only in one out of four analyzed datasets (Fig. 2A–D and Supplementary Figure S1A–D). The gene discussed is CASP8; the disease is Familial prostate cancer.