PROC and cancer: Aside from the leading upregulated and downregulated genes in patients with GE cancers, we also noted a stage-wise upregulation of several genes, such as APOC2, IL8, RNASE2, SERPINE1, and CETP, and stage-wise downregulation of other genes that play important role in and survival, including AHNAK, MEGF8, MMRN1, PROC, REG1A, SECTM1, TNFRSF10C, and TPPP3.