C16orf89 and esophageal cancer: Our analysis showed that following five genes were most significantly downregulated in esophageal cancer: C16orf89 (9.78E−08), AR (1.01E−07), CKB (1.17E−07), ADH1B (1.79E−07), and NCAM1 (2.15E−07) (Fig. 4A).