The comparison between esophageal tumors and healthy tissue showed BIRC5 (p = 2.61E−08), APOC2 (p = 3.23E−08), CENPF (p = 4.38E−08), STMN1 (p = 5.74E−08), and HNRPC (p = 8.21E−08) to be five leading genes overexpressed in esophageal cancer (Fig. 1A). The gene discussed is CENPF; the disease is esophageal cancer.