The stage-wise analysis also revealed a progressive downregulation of the following genes from stage I to IV stomach cancer: ACAA1, AZGP1, BLVRB, CYB5A, EPHX2, FBP1, REG1A, SECTM1, SELENBP1, and TPPP3 (Fig. 4E,F). This evidence concerns the gene CYB5A and gastric cancer.