However, the stage-wise analysis showed a gradual downregulation of the following genes from stage I to IV esophageal cancer: AHNAK, APOM, ART3, CAMK2D, MB, MEGF8, MMRN1, PROC, S100A1, and TNFRSF10C (Fig. 4B). This evidence concerns the gene MEGF8 and esophageal cancer.