Recent vGWAS have found evidence for loci with variance effects on BMI located in genes responsible for adipocyte differentiation (PPARG) and genes implicated in the pathology of obesity, diabetes, atherosclerosis, and cancer (FTO, PPARG, CCNL1, TCF7L2, ZNF668, GIPR)16. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.