Recent vGWAS have found evidence for loci with variance effects on BMI located in genes responsible for adipocyte differentiation (PPARG) and genes implicated in the pathology of obesity, diabetes, atherosclerosis, and cancer (FTO, PPARG, CCNL1, TCF7L2, ZNF668, GIPR)16. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.