NDUFA4L2 was also found to be a direct transcriptional target of hypoxia-inducible factor (HIF)-1α; knockdown of NDUFA4L2 or inhibition of HIF-1α led to marked suppression of tumor growth and metastasis, suggesting that patients with hepatocellular carcinoma patients who exhibit NDUFA4L2 overexpression may be suitable candidates for HIF inhibitor treatment. The gene discussed is COXFA4L2; the disease is hepatocellular carcinoma.