HIF1A and neoplasm: NDUFA4L2 was also found to be a direct transcriptional target of hypoxia-inducible factor (HIF)-1α; knockdown of NDUFA4L2 or inhibition of HIF-1α led to marked suppression of tumor growth and metastasis, suggesting that patients with hepatocellular carcinoma patients who exhibit NDUFA4L2 overexpression may be suitable candidates for HIF inhibitor treatment.